Songfacts®:

• Sepsis is a life-threatening medical condition triggered by infection. In this song, it's a metaphor for social decay, death cults, populism, and the sense that civilization is held together with the moral equivalent of duct tape. The song is delivered by Randy Blythe in his lowest register, a departure from his typical vocal approach with Lamb of God.
• The track also functions as a love letter to the early 1990s underground scene in Lamb of God's hometown of Richmond, Virginia. "Bands like Breadwinner, Sliang Laos, and Ladyfinger, though they never got widespread attention outside of Richmond, those were the bands we listened to all the time," said guitarist Mark Morton. "The song references that stuff in a way that's a direct line to where we were coming from when we were in the basement writing our earliest material together."
• Longtime producer Josh Wilbur's production layers brutality with precision. Wilbur has manned the boards for Lamb Of God since their 2009 album Wrath.
• The lo-fi performance video, filmed by Gianfranco Svagelj, offers a grainy glimpse into Richmond's underbelly.
• "Sepsis" dropped on October 2, 2025, marking the band's first original material since 2022's Omens. They debuted it live the next day at California's Aftershock Festival, where Randy Blythe introduced it by saying, "This song is about a national sickness. It's called 'Sepsis.'"