Songfacts®:

• In this song, Petty sings about driving into the great wide open, with nothing but glorious possibility in his path.
  
  Petty started running down his dream of being a rocker in 1961 when he met Elvis Presley. Petty, 11 years old, came to the Ocala, Florida, set where Elvis was working on the film Follow That Dream - a title Tom took to heart. In a brief encounter, Petty saw how Elvis captivated onlookers and made the girls go crazy. Petty became fascinated with Elvis and set out to follow his path.
• The animated video was inspired by a comic strip called Little Nemo In Slumberland by Winsor McKay. Each strip told the story of one of Nemo's dreams, and at the end, he always woke up.
• Full Moon Fever was listed as a Tom Petty solo album even though members of The Heartbreakers played on it. Petty had another band at this time as well: the Traveling Wilburys, which included Jeff Lynne, who co-produced the album and played many of the instruments.
• Heartbreakers' guitarist Mike Campbell wrote this with Petty and Jeff Lynne. The three of them worked on the album at Campbell's house.
  
  Petty and Campbell were very impressed with Lynne's production techniques, and learned a lot from the experience. Campbell gave Songfacts an example of Lynne's style: "We'd put the mics up on the drums, and he'd walk out and take the microphone over the drum and he'd turn it away from the drum facing the corner, and he'd go 'OK, record it like that.' Sure enough, 99% of the time he'd be right. We'd go, 'Yes sir, Mr. Lynne.' We learned so much from him about arrangements and countermelodies and all kinds of stuff."
• The line, "Me and Del were singin,' little 'Runaway'" is a reference to the 1961 Del Shannon hit "Runaway." Shannon is credited on the album for "barnyard noises," which can be heard just after this song ends on the album. Under the animal noises, Petty says, "Hello CD listeners. We have come to the point in this album where those listening on cassettes or records will have to stand - up or sit down - and turn over the record or tape. In fairness to those listeners, we will now take a few seconds before we begin Side 2. Thank you, and here is Side 2."
  
  Those noises were made by Shannon and Jeff Lynne; Petty used them as an interlude to mark the middle of the album, because you don't have to flip over a CD. This section was included only on CD versions of Full Moon Fever, but survived the transition when the album was released digitally.
• In 2007, the documentary Runnin' Down A Dream was released. Directed by Peter Bogdanovich, the film chronicles the career of Tom Petty and the Heartbreakers. >>

  Suggestion credit:
  Bertrand - Paris, France
• Tom Petty and the Heartbreakers played this at the halftime show of the Super Bowl in 2008. Rather than the usual medley of hits, the band played four full songs, the others being "American Girl," "I Won't Back Down" and "Free Fallin'."
• The song is used in the 2004 video game Grand Theft Auto: San Andreas, where it shows up on the radio station K-DST. In 2023, another Full Moon Fever track, "Love Is A Long Road," soundtracked the trailer for Grand Theft Auto VI.