"Johnny B. Goode" was the only rock song included on the "Golden Records" that were sent into space aboard the Voyager 1 and Voyager 2 space probes in 1977. The identical records (one for each craft) contain folk songs from around the word, selections from Bach and Mozart, and greetings in 55 languages. 
"I Ran (So Far Away)" by A Flock Of Seagulls ends with an alien abduction.

Thanks to Eminem's song, the word "stan" was added to the Oxford American Dictionary in 2017. It means an obsessive fan.

"Sloop John B" is a traditional West Indian folk song, and it was a huge hit for The Beach Boys in 1966. They tweaked the lyric, "This is the worst trip since I've been born" to "...I've ever been on" as a wink to acid culture.

The Matchbox Twenty song "3 AM" is about the difficult times lead singer Rob Thomas spent caring for his mother, who had cancer.

When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.

Pink wrote "Just Give Me A Reason" about how one partner can feel jilted over something trivial, like how her boyfriend passes her the butter.
Oliver Leiber talks about writing and producing hits for Paula Abdul, and explains his complicated relationship with his father, the songwriter Jerry Leiber.
Deep Purple frontman Ian Gillan explains the "few red lights" in "Smoke On The Water" and talks about songs from their 2020 album Whoosh!
The lead singer and pianist for Procol Harum, Gary talks about finding the musical ideas to match the words.
Glen Ballard talks about co-writing and producing Alanis Morissette's Jagged Little Pill album, and his work with Dave Matthews, Aerosmith and Annie Lennox.
From "Some Day My Prince Will Come" to "Let It Go" - how Disney princess songs (and the women who sing them) have evolved.
What happens when Kurt Cobain, Iron Maiden and Johnny Lydon are told to lip-synch? Some hilarious "performances."